PSMD13 Recombinant Rabbit Monoclonal Antibody [PSH0-52] (HA721399)

UNIPROT #

Q9UNM6

PROTEIN NAME

PSMD13

SYNONYMS

26S proteasome non ATPase regulatory subunit 13 antibody;26S proteasome non-ATPase regulatory subunit 13 antibody;26S proteasome regulatory subunit p40.5 antibody;26S proteasome regulatory subunit RPN9 antibody;26S proteasome regulatory subunit S11 antibody;26S proteasome subunit p40.5 antibody;HSPC027 antibody;P40.5 antibody;Proteasome (prosome, macropain) 26S subunit, non ATPase, 13 antibody;Proteasome 26S subunit, non-ATPase 13 antibody;PSD13_HUMAN antibody;psmD13 antibody;Rpn9 antibody;S11 antibody

SUBCELLULAR LOCATION

Proteasome, cytosol, extracellular region, nucleoplasm, nucleus.

FUNCTION

26S proteasome non-ATPase regulatory subunit 13 is an enzyme that in humans is encoded by the PSMD13 gene. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Two transcripts encoding different isoforms have been described.