PSMD11 Rabbit Polyclonal Antibody (HA500414)

UNIPROT #

O00231

PROTEIN NAME

PSMD11

SYNONYMS

26S proteasome non-ATPase regulatory subunit 11 antibody;26S proteasome regulatory subunit 9 antibody;26S proteasome regulatory subunit p44.5 antibody;26S proteasome regulatory subunit RPN6 antibody;26S proteasome regulatory subunit S9 antibody;MGC3844 antibody;p44.5 antibody;protease 26S, subunit, 9 antibody;proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 antibody;proteasome 26S subunit, non-ATPase, 11 antibody;PSD11_HUMAN antibody;PSMD 11 antibody;PSMD11 antibody;Rpn6 antibody;S9 antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis. SCF(BTRC) mediates the ubiquitination and subsequent degradation of nuclear NFE2L1 (By similarity). Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2. May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3. Mediates ubiquitination of REST, thereby leading to its proteasomal degradation. SCF(BTRC) mediates the ubiquitination and subsequent proteasomal degradation of KLF4; thereby negatively regulating cell pluripotency maintenance and embryogenesis (By similarity).