PSMB7 Rabbit Polyclonal Antibody (HA500345)

UNIPROT #

Q99436

PROTEIN NAME

PSMB7

SYNONYMS

Macropain chain Z antibody;Multicatalytic endopeptidase complex chain Z antibody;Proteasome (prosome macropain) subunit beta type 7 antibody;Proteasome beta 7 subunit antibody;Proteasome catalytic subunit 2 antibody;Proteasome subunit alpha antibody;Proteasome subunit beta 7 antibody;Proteasome subunit beta type-7 antibody;Proteasome subunit Z antibody;PSB7_HUMAN antibody;PSMB7 antibody;PUP1 antibody;Z antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

Proteasome subunit beta type-7 as known as 20S proteasome subunit beta-2 is a protein that in humans is encoded by the PSMB7 gene. The proteasome and its subunits are of clinical significance for at least two reasons: (1) a compromised complex assembly or a dysfunctional proteasome can be associated with the underlying pathophysiology of specific diseases, and (2) they can be exploited as drug targets for therapeutic interventions. More recently, more effort has been made to consider the proteasome for the development of novel diagnostic markers and strategies. An improved and comprehensive understanding of the pathophysiology of the proteasome should lead to clinical applications in the future. The proteasomes form a pivotal component for the ubiquitin–proteasome system (UPS) and corresponding cellular Protein Quality Control (PQC). Protein ubiquitination and subsequent proteolysis and degradation by the proteasome are important mechanisms in the regulation of the cell cycle, cell growth and differentiation, gene transcription, signal transduction and apoptosis. Subsequently, a compromised proteasome complex assembly and function lead to reduced proteolytic activities and the accumulation of damaged or misfolded protein species. Such protein accumulation may contribute to the pathogenesis and phenotypic characteristics in neurodegenerative diseases, cardiovascular diseases, inflammatory responses and autoimmune diseases, and systemic DNA damage responses leading to malignancies.