PSMB5 / MB1 Rabbit Polyclonal Antibody (HA500533)

UNIPROT #

P28074

PROTEIN NAME

PSMB5 / MB1

SYNONYMS

DKFZp459C139 antibody;EC 3.4.25.1 antibody;LMPX antibody;Macropain epsilon chain antibody;MB1 antibody;MGC104214 antibody;MGC118075 antibody;MGC134464 antibody;Multicatalytic endopeptidase complex epsilon chain antibody;Proteasome (prosome, macropain) subunit, beta type, 5 antibody;Proteasome beta 5 subunit antibody;Proteasome catalytic subunit 3 antibody;Proteasome chain 6 antibody;Proteasome epsilon chain antibody;Proteasome subunit beta type-5 antibody;Proteasome subunit MB1 antibody;Proteasome subunit X antibody;Proteasome subunit, beta type, 5 antibody;Proteasome subunit, beta-5 antibody;PSB5_HUMAN antibody;PSMB5 antibody;PSX large multifunctional protease X antibody;X antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. This catalytic subunit is not present in the immunoproteasome and is replaced by catalytic subunit 3i (proteasome beta 8 subunit). Multiple transcript variants encoding different isoforms have been found for this gene.