PSMB10 Rabbit Polyclonal Antibody (HA500393)

UNIPROT #

P40306

PROTEIN NAME

PSMB10

SYNONYMS

beta2i antibody;FLJ00366 antibody;LMP10 antibody;Low molecular mass protein 10 antibody;Macropain subunit MECl 1 antibody;Macropain subunit MECl-1 antibody;MECL1 antibody;MGC1665 antibody;Multicatalytic endopeptidase complex subunit MECl 1 antibody;Multicatalytic endopeptidase complex subunit MECl-1 antibody;OTTHUMP00000174858 antibody;Proteasome (prosome macropain) subunit beta type 10 antibody;Proteasome beta 10 subunit antibody;Proteasome catalytic subunit 2i antibody;Proteasome MECl 1 antibody;Proteasome MECl-1 antibody;Proteasome subunit beta 2i antibody;Proteasome subunit beta 7i antibody;Proteasome subunit beta type 10 antibody;Proteasome subunit beta type-10 antibody;Proteasome subunit beta-2i antibody;Proteasome subunit MECL1 antibody;PSB10_HUMAN antibody;PSMB 10 antibody;Psmb10 antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

Proteasome subunit beta type-10 as known as 20S proteasome subunit beta-2i is a protein that in humans is encoded by the PSMB10 gene. This protein has a major role in the immune system as part of an immunoproteasome that is primarily induced upon infection and formed by replacing constitutive beta subunits with inducible beta subunits which possess specific cleavage properties that aid in the release of peptides necessary for MHC class I antigen presentation. The immunoproteasome appears to have a pivotal role in modulating NFκB signaling. The proteasome and its subunits are of clinical significance for at least two reasons: (1) a compromised complex assembly or a dysfunctional proteasome can be associated with the underlying pathophysiology of specific diseases, and (2) they can be exploited as drug targets for therapeutic interventions. The proteasomes form a pivotal component for the ubiquitin–proteasome system (UPS) and corresponding cellular Protein Quality Control (PQC). Protein ubiquitination and subsequent proteolysis and degradation by the proteasome are important mechanisms in the regulation of the cell cycle, cell growth and differentiation, gene transcription, signal transduction and apoptosis. During the antigen processing for the major histocompatibility complex (MHC) class-I, the proteasome is the major degradation machinery that degrades the antigen and present the resulting peptides to cytotoxic T lymphocytes. The immunoproteasome has been considered playing a critical role in improving the quality and quantity of generated class-I ligands.