PSMA5 Rabbit Polyclonal Antibody (ER2001-68)

UNIPROT #

P28066

PROTEIN NAME

PSMA5

SYNONYMS

Macropain zeta chain antibody;Multicatalytic endopeptidase complex zeta chain antibody;Proteasome (prosome macropain) subunit alpha type 5 antibody;Proteasome alpha5 subunit antibody;Proteasome component 5 antibody;Proteasome subunit alpha type 5 antibody;Proteasome subunit alpha type-5 antibody;Proteasome subunit zeta antibody;Proteasome zeta chain antibody;PSA5_HUMAN antibody;PSC5 antibody;PSMA5 antibody;ZETA antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus, Proteasome.

FUNCTION

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).