Positive control:
Lane 1: Hela cell lysate
Lane 2: 293 cell lysate
Lane 3: Mouse cerebellum tissue lysate
Lane 4: Mouse liver tissue lysate
Lane 5: Rat liver tissue lysate
Applications
-
WB
-
IHC
REACTIVITY
-
Human
-
Mouse
-
Rat
SPECIFICATIONS
Product Type
Rabbit polyclonal primary
Product Name
PSMA5 Rabbit Polyclonal Antibody (ER2001-68)
Immunogen
Recombinant protein within human psma5 aa 1-200.
Host
Rabbit
Positive Control
Hela cell lysate, 293 cell lysate, mouse cerebellum tissue lysate, mouse liver tissue lysate, rat liver tissue lysate, human liver carcinoma tissue, human colon carcinoma tissue.
Conjugation
Unconjugated
Clonality
Polyclonal
PROPERTIES
Form
Liquid
Storage Condition
Store at +4Á¾ after thawing. Aliquot store at -20Á¾. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 ug/ul
PURIFICATION
Protein affinity purified.
MOLECULAR WEIGHT
26 kDa
Isotype
IgG
APPLICATION DILUTION
-
WB
-
1:500-1:1,000
-
IHC
-
1:100-1:500
TARGET
UNIPROT #
PROTEIN NAME
PSMA5
SYNONYMS
Macropain zeta chain antibody; Multicatalytic endopeptidase complex zeta chain antibody; Proteasome (prosome macropain) subunit alpha type 5 antibody; Proteasome alpha5 subunit antibody; Proteasome component 5 antibody; Proteasome subunit alpha type 5 antibody; Proteasome subunit alpha type-5 antibody; Proteasome subunit zeta antibody; Proteasome zeta chain antibody; PSA5_HUMAN antibody; PSC5 antibody; PSMA5 antibody; ZETA antibody
SUBCELLULAR LOCATION
Cytoplasm, Nucleus, Proteasome.
FUNCTION
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).