PSMA4 Rabbit Polyclonal Antibody (HA500452)

UNIPROT #

P25789

PROTEIN NAME

PSMA4

SYNONYMS

HC9 antibody;HsT17706 antibody;Macropain subunit C9 antibody;MGC111191 antibody;MGC12467 antibody;MGC24813 antibody;Multicatalytic endopeptidase complex subunit C9 antibody;Proteasome (prosome macropain) subunit alpha type 4 antibody;Proteasome alpha 4 subunit antibody;Proteasome component C9 antibody;Proteasome subunit alpha type 4 antibody;Proteasome subunit alpha type-4 antibody;Proteasome subunit HC9 antibody;Proteasome subunit L antibody;PSA4_HUMAN antibody;PSC9 antibody;PSMA 4 antibody;psmA4 antibody

SUBCELLULAR LOCATION

Cytoplasm. Nucleus. Cytoplasm, P-body.

FUNCTION

Crystal structures of isolated 20S proteasome complex demonstrate that the two rings of beta subunits form a proteolytic chamber and maintain all their active sites of proteolysis within the chamber.[9] Concomitantly, the rings of alpha subunits form the entrance for substrates entering the proteolytic chamber. In an inactivated 20S proteasome complex, the gate into the internal proteolytic chamber are guarded by the N-terminal tails of specific alpha-subunit. The proteolytic capacity of 20S core particle (CP) can be activated when CP associates with one or two regulatory particles (RP) on one or both side of alpha rings. These regulatory particles include 19S proteasome complexes, 11S proteasome complex, etc. Following the CP-RP association, the confirmation of certain alpha subunits will change and consequently cause the opening of substrate entrance gate. Besides RPs, the 20S proteasomes can also be effectively activated by other mild chemical treatments, such as exposure to low levels of sodium dodecylsulfate (SDS) or NP-14. The eukaryotic proteasome recognized degradable proteins, including damaged proteins for protein quality control purpose or key regulatory protein components for dynamic biological processes. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. As a component of alpha ring, proteasome subunit alpha type-4 contributes to the formation of heptameric alpha rings and substrate entrance gate. Importantly, this subunit plays an critical role in the assembly of 19S base and 20S.