PSMA2 Recombinant Rabbit Monoclonal Antibody [JE51-51] (ET7110-19)

UNIPROT #

P25787

PROTEIN NAME

PSMA2

SYNONYMS

HC3 antibody;Macropain subunit C3 antibody;MU antibody;Multicatalytic endopeptidase complex subunit C3 antibody;PMSA2 antibody;Proteasome (prosome macropain) subunit alpha type 2 antibody;Proteasome alpha 2 subunit antibody;Proteasome component C3 antibody;Proteasome subunit alpha type 2 antibody;Proteasome subunit alpha type-2 antibody;Proteasome subunit HC3 antibody;PSA2_HUMAN antibody;PSC2 antibody;PSC3 antibody;PSMA 2 antibody;psmA2 antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase T1A family.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated on tyrosine residues; which may be important for nuclear import.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus, Proteasome.

FUNCTION

Crystal structures of isolated 20S proteasome complex demonstrate that the two rings of beta subunits form a proteolytic chamber and maintain all their active sites of proteolysis within the chamber. Concomitantly, the rings of alpha subunits form the entrance for substrates entering the proteolytic chamber. In an inactivated 20S proteasome complex, the gate into the internal proteolytic chamber are guarded by the N-terminal tails of specific alpha-subunit. The proteolytic capacity of 20S core particle (CP) can be activated when CP associates with one or two regulatory particles (RP) on one or both side of alpha rings. These regulatory particles include 19S proteasome complexes, 11S proteasome complex, etc. Following the CP-RP association, the confirmation of certain alpha subunits will change and consequently cause the opening of substrate entrance gate. Besides RPs, the 20S proteasomes can also be effectively activated by other mild chemical treatments, such as exposure to low levels of sodium dodecylsulfate (SDS) or NP-14. The eukaryotic proteasome recognized degradable proteins, including damaged proteins for protein quality control purpose or key regulatory protein components for dynamic biological precesses. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides.