PSD95 Recombinant Rabbit Monoclonal Antibody [SR38-09] (ET1602-20)

UNIPROT #

P78352

PROTEIN NAME

PSD95

SYNONYMS

Discs large homolog 4 antibody;Disks large homolog 4 antibody;DLG 4 antibody;Dlg4 antibody;DLG4_HUMAN antibody;FLJ97752 antibody;FLJ98574 antibody;Human post synaptic density protein 95 antibody;Post synaptic density protein 95 antibody;Postsynaptic density protein 95 antibody;PSD 95 antibody;PSD-95 antibody;PSD95 antibody;SAP 90 antibody;SAP-90 antibody;SAP90 antibody;Synapse associated protein 90 antibody;Synapse-associated protein 90 antibody;Tax interaction protein 15 antibody

SEQUENCE SIMILARITIES

Belongs to the MAGUK family.

TISSUE SPECIFICITY

Brain.

POST-TRANSLATIONAL MODIFICATION

Palmitoylated. Palmitoylation is required for targeting to postsynaptic density, plasma membrane and synapses (By similarity). Palmitoylation by ZDHHC2 occurs when the synaptic activity decreases and induces DLG4 synaptic clustering (By similarity). Palmitoylation may play a role in glutamate receptor GRIA1 synapse clustering (By similarity). Depalmitoylated by ABHD17A and ABHD17B and to a lesser extent by ABHD17C, ABHD12, ABHD13, LYPLA1 and LYPLA2. Undergoes rapid synaptic palmitoylation/depalmitoylation cycles during neuronal development which slow down in mature neurons (By similarity).; Ubiquitinated by MDM2 in response to NMDA receptor activation, leading to proteasome-mediated degradation of DLG4 which is required for AMPA receptor endocytosis.

SUBCELLULAR LOCATION

Cell membrane, Postsynaptic density, Synapse, Cytoplasm, Cell projection, axon, dendritic spine, dendrite, Presynapse.

FUNCTION

PSD-95 (postsynaptic density protein 95) also known as SAP-90 (synapse-associated protein 90) is a protein that in humans is encoded by the DLG4 (discs large homolog 4) gene. PSD-95 is a member of the membrane-associated guanylate kinase (MAGUK) family. With PSD-93 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. PSD-95 is the best studied member of the MAGUK-family of PDZ domain-containing proteins. Like all MAGUK-family proteins, its basic structure includes three PDZ domains, an SH3 domain, and a guanylate kinase-like domain (GK) connected by disordered linker regions. It is almost exclusively located in the post synaptic density of neurons, and is involved in anchoring synaptic proteins. Its direct and indirect binding partners include neuroligin, NMDA receptors, AMPA receptors, and potassium channels. It plays an important role in synaptic plasticity and the stabilization of synaptic changes during long-term potentiation.