PRSS2 Rabbit Polyclonal Antibody (HA500182)

UNIPROT #

P07478

PROTEIN NAME

PRSS2

SYNONYMS

Anionic trypsinogen antibody;EC 3.4.21.4 antibody;MGC111183 antibody;MGC120174 antibody;Protease serine 2 preproprotein antibody;Protease, serine, 2 (trypsin 2) antibody;Protease, serine, 2 antibody;Protease, serine, 2, preproprotein antibody;Prss2 antibody;Serine protease 2 antibody;TRY2 antibody;TRY2_HUMAN antibody;TRY8 antibody;TRYP2 antibody;Trypsin 2 antibody;Trypsin II antibody;Trypsin-2 antibody;Trypsinogen 2 antibody

SUBCELLULAR LOCATION

Extracellular space.

FUNCTION

This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.