PRR5 Rabbit Polyclonal Antibody (HA500295)

UNIPROT #

P85299

PROTEIN NAME

PRR5

SYNONYMS

Arhgap8 antibody;AU043908 antibody;C030017C09Rik antibody;C78947 antibody;FLJ20185 antibody;FLJ20185k antibody;MGC109513 antibody;MGC32512 antibody;PP610 antibody;Proline rich 5 (renal) antibody;Proline-rich protein 5 antibody;Protein observed with Rictor-1 antibody;Protor-1 antibody;PROTOR1 antibody;PRR5 antibody;PRR5_HUMAN antibody;PTOR1 antibody;Rho GTPase activating protein 8 antibody;RP1-181C9.3 antibody

SUBCELLULAR LOCATION

Cytosol.

FUNCTION

Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer.