Rabbit polyclonal primary
Protocadherin Fat 1 Rabbit Polyclonal Antibody (0905-4)
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Immunogen affinity purified
Protocadherin Fat 1
Cadherin family member 7 antibody; Cadherin family member 7 precursor antibody; Cadherin ME5 antibody; Cadherin related tumor suppressor antibody; Cadherin related tumor suppressor homolog antibody; Cadherin related tumor suppressor homolog precursor antibody; Cadherin related tumor suppressor homolog precursor (FAT protein homolog) antibody; Cadherin-related tumor suppressor homolog antibody; CDHF 7 antibody; CDHF7 antibody; FAT 1 antibody; FAT tumor suppressor 1 antibody; FAT tumor suppressor homolog 1 antibody; FAT1 antibody; FAT1_HUMAN antibody; hFat 1 antibody; hFAT antibody; hFat1 antibody; Homolog of Drosophila FAT protein antibody; Homolog of Drosophila FAT protein precursor antibody; Homolog of Drosophila tumor suppressor FAT precursor antibody; ME 5 antibody; ME5 antibody; nuclear form antibody; Protein fat homolog antibody
Expressed in many epithelial and some endothelial and smooth muscle cells.
Undergoes proteolytic cleavage. The extracellular domain is cleaved off and the cytoplasmic domain (about 400 AA) shuttles to the nucleus.
Mammalian FAT1 is a large transmembrane protein of the protocadherin superfamily ?rst identi?ed in Drosophila melanogaster. FAT1 is widely expressed in mammalian tissues, and it is particularly enriched in kidney glomerular epithelial cells. Human Protocadherin Fat1 is a single-pass type I membrane protein, contains 4950 amino acids. It may play an important role in regulating growth and cell adhesion.