Proteasome 20S LMP2 Recombinant Rabbit Monoclonal Antibody [JB35-07] (ET7107-24)

UNIPROT #

P28065

PROTEIN NAME

Proteasome 20S LMP2

SYNONYMS

Beta1i antibody;Large multifunctional peptidase 2 antibody;Large multifunctional protease 2 antibody;LMP 2 antibody;LMP2 antibody;Low molecular mass protein 2 antibody;Macropain chain 7 antibody;MGC70470 antibody;Multicatalytic endopeptidase complex chain 7 antibody;OTTHUMP00000062982 antibody;Proteasome (prosome macropain) subunit beta type 9 antibody;proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) antibody;Proteasome beta 9 subunit antibody;Proteasome catalytic subunit 1i antibody;Proteasome chain 7 antibody;Proteasome related gene 2 antibody;Proteasome subunit beta 6i antibody;Proteasome subunit beta type 9 antibody;Proteasome subunit beta type-9 antibody;Proteasome subunit beta-1i antibody;PSB9_HUMAN antibody;PSMB 9 antibody;PSMB6i antibody;PSMB9 antibody;Really interesting new gene 12 protein antibody;RING 12 antibody;RING12 antibody;RING12 protein antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase T1B family.

DEVELOPMENTAL STAGE

Highly expressed in immature dendritic cells (at protein level).

POST-TRANSLATIONAL MODIFICATION

Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity.

SUBCELLULAR LOCATION

Cytoplasm. Nucleus.

FUNCTION

Proteasome subunit beta type-9 as known as 20S proteasome subunit beta-1i is a protein that in humans is encoded by the PSMB9 gene. This protein is one of the 17 essential subunits (alpha subunits 1-7, constitutive beta subunits 1-7, and inducible subunits including beta1i, beta2i, beta5i) that contributes to the complete assembly of 20S proteasome complex. In particular, proteasome subunit beta type-5, along with other beta subunits, assemble into two heptameric rings and subsequently a proteolytic chamber for substrate degradation. This protein contains "Trypsin-like" activity and is capable of cleaving after basic residues of peptide. The eukaryotic proteasome recognized degradable proteins, including damaged proteins for protein quality control purpose or key regulatory protein components for dynamic biological processes. The constitutive subunit beta1, beta2, and beta 5 (systematic nomenclature) can be replaced by their inducible counterparts beta1i, 2i, and 5i when cells are under the treatment of interferon-γ. The resulting proteasome complex becomes the so-called immunoproteasome. An essential function of the modified proteasome complex, the immunoproteasome, is the processing of numerous MHC class-I restricted T cell epitopes.