Proteasome 20S beta 6 Rabbit Polyclonal Antibody (HA500349)

UNIPROT #

P28072

PROTEIN NAME

Proteasome 20S beta 6

SYNONYMS

DELTA antibody;LMPY antibody;Macropain delta chain antibody;MGC5169 antibody;Multicatalytic endopeptidase complex delta chain antibody;Proteasome (prosome macropain) subunit beta type 6 antibody;Proteasome beta 6 subunit antibody;Proteasome catalytic subunit 1 antibody;Proteasome delta chain antibody;Proteasome subunit beta 6 antibody;Proteasome subunit beta type 6 antibody;Proteasome subunit beta type-6 antibody;Proteasome subunit delta antibody;Proteasome subunit Y antibody;PSB6_HUMAN antibody;PSMB6 antibody;PSY large multifunctional protease Y antibody;Y antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

In eukaryotic cells, selective breakdown of cellular proteins is ensured by their ubiquitination and subsequent degradation by the 26S Proteasome. The 26S Proteasome is a protease complex that selectively breaks down proteins that have been modified by polyubiquitin chains. It is made up of two multisubunit complexes: the 20S Proteasome chamber, which serves as the proteolytic core of the complex and two 19S regulatory particles which recognize and unfold ubiquitinated proteins. The 20S Proteasome chamber contains α subunits (which are structural) and β subunits (which are predominantly catalytic). The outer two rings in the proteasome consist of seven α subunits each, and the inner two rings each consist of seven β subunits. PSMB6 (proteasome (prosome, macropain) subunit, β type, 6), also known as LMPY (PSY large multifunctional protease Y), macropain δ chain, proteasome δ chain or proteasome subunit Y, is a β subunit of the 20S Proteasome and, upon stimulation with IFN-γ, can be displaced by LMP2.