PRMT5 Rabbit Polyclonal Antibody (R1204-3)

UNIPROT #

O14744

PROTEIN NAME

PRMT5

SYNONYMS

72 kDa ICln binding protein antibody;72 kDa ICln-binding protein antibody;ANM5_HUMAN antibody;Histone synthetic lethal 7, S. cerevisiae, homolog of antibody;Histone-arginine N-methyltransferase PRMT5 antibody;HMT1 hnRNP methyltransferase like 5 antibody;HOMOLOG OF; SKB1 antibody;HRMT1L5 antibody;IBP72 antibody;Jak-binding protein 1 antibody;JBP 1 antibody;JBP1 antibody;PRMT 5 antibody;PRMT5 antibody;Protein arginine methyltransferase 5 antibody;Protein arginine N methyltransferase 5 antibody;Protein arginine N methyltransferase 5 N terminally processed antibody;Protein arginine N-methyltransferase 5 antibody;S. POMBE antibody;S. POMBE HOMOLOG OF; SKB1 antibody;SHK1 KINASE BINDING PROTEIN 1 antibody;Shk1 kinase binding protein 1 homolog antibody;Shk1 kinase-binding protein 1 homolog antibody;Shk1 kinase/binding protein 1, S. pombe, homolog of antibody;SKB 1 antibody;SKB1 antibody;SKB1 homolog antibody;SKB1: SKB1 homolog (S. pombe) antibody;SKB1Hs antibody

SEQUENCE SIMILARITIES

Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.

TISSUE SPECIFICITY

Ubiquitous.

SUBCELLULAR LOCATION

Cytoplasm, nucleus

FUNCTION

This gene encodes an enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the amino acid arginine, in target proteins that include histones, transcriptional elongation factors and the tumor suppressor p53. This gene plays a role in several cellular processes, including transcriptional regulation, and the assembly of small nuclear ribonucleoproteins. A pseudogene of this gene has been defined on chromosome 4. Alternative splicing results in multiple transcript variants encoding different isoforms. PRMT5 is a highly conserved arginine methyltransferase that translocated from the cytoplasm to the nucleus at embryonic day ~E8.5, and during preimplantation development at the ~4-cell stage. Model organisms have been used in the study of PRMT5 function. A conditional knockout mouse line, called Prmt5tm2a(EUCOMM)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.