PRMT1 Recombinant Rabbit Monoclonal Antibody [JA11-17] (ET1704-19)

UNIPROT #

Q99873

PROTEIN NAME

PRMT1

SYNONYMS

ANM 1 antibody;ANM1 antibody;ANM1_HUMAN antibody;HCP 1 antibody;HCP1 antibody;Heterogeneous nuclear ribonucleoprotein methyltransferase 1 like 2 antibody;Heterogeneous nuclear ribonucleoproteins methyltransferase like 2 antibody;Heterogeneous nuclear ribonucleoproteins methyltransferase like2 antibody;Histone-arginine N-methyltransferase PRMT1 antibody;HMT 2 antibody;HMT1 (hnRNP methyltransferase S. cerevisiae) like 2 antibody;HMT1 hnRNP methyltransferase antibody;HMT1 hnRNP methyltransferase like 2 (S. cerevisiae) antibody;HMT1 hnRNP methyltransferase like 2 antibody;HMT2 antibody;HRMT1 L2 antibody;HRMT1L 2 antibody;HRMT1L2 antibody;Human mRNA for suppressor for yeast mutant antibody;Human mRNA for suppressor for yeast mutant complete cds antibody;Interferon receptor 1 bound protein 4 antibody;Interferon receptor 1 bound protein4 antibody;Interferon receptor 1-bound protein 4 antibody;Interferon receptor 1bound protein 4 antibody;IR1 B4 antibody;IR1B 4 antibody;IR1B4 antibody;Mrmt 1 antibody;Mrmt1 antibody;PRMT 1 antibody;PRMT1 antibody;Protein arginine methyltransferase 1 antibody;Protein arginine N methyltransferase 1 antibody;Protein arginine N methyltransferase1 antibody;Protein arginine N-methyltransferase 1 antibody;R1B4 antibody;S. cerevisiae like 2 antibody

SEQUENCE SIMILARITIES

Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.

TISSUE SPECIFICITY

Widely expressed. Expressed strongly in colorectal cancer cells (at protein level). Expressed strongly in colorectal cancer tissues compared to wild-type colon samples (at protein level). Expressed strongly in colorectal cancer tissues compared to wild-type colon samples.

POST-TRANSLATIONAL MODIFICATION

Polyubiquitinated at Lys-145 by the SCF(FBXL17) complex, leading to its subsequent degradation. Ubiquitination is regulated by acetylation at Lys-228 and Lys-233.; Acetylation at Lys-228 and Lys-233 regulates ubiquitination by the SCF(FBXL17) complex. Acetylated at Lys-233 by p300/EP300. Deacetylated at Lys-228 and Lys-233 by SIRT1.

SUBCELLULAR LOCATION

Nucleus. Cytoplasm.

FUNCTION

A class of proteins termed type 1 protein arginine N-methyltransferase (PRMT) enzymes contribute to posttranslational modification of RNA-binding proteins, but differ in substrate specificities, oligomerization properties and subcellular localization. PRMT1, the predominant form in mammalian cells, is located in the nucleus, while PRMT3 is present in the cytoplasm. At the carboxy-terminus, interleukin enhancer-binding factor 3 (ILF3) binds PRMT1, thereby regulating PRMT1 activitiy. Alternative mRNA splicing of the PRMT gene results in three isoforms of PRMT1 that differ in their amino-terminus regions. All three splice variants of PRMT1 are enzymatically active. PRMT3 recognizes and binds to RNA-associated substrates with a zinc-finger domain in its amino-terminus. The zinc-liganded form of this domain is required for the enzyme to recognize RNA-associated substrates.