PPP2R1B Rabbit Polyclonal Antibody (HA500383)

UNIPROT #

P30154

PROTEIN NAME

PPP2R1B

SYNONYMS

2AAB_HUMAN antibody;beta isoform of regulatory subunit A, protein phosphatase 2 antibody;PP2A A beta antibody;PP2A subunit A isoform PR65-beta antibody;PP2A subunit A isoform R1-beta antibody;PP2A, subunit A, PR65 beta isoform antibody;PP2A, subunit A, R1 beta isoform antibody;PPP2R1B antibody;PPP4R1 antibody;PR65B antibody;protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform antibody;protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform antibody;Protein phosphatase 2, regulatory subunit A, beta antibody;Protein phosphatase 2, structural/regulatory subunit A, beta antibody;protein phosphatase 2, structural/regulatory subunit A, beta isoform antibody;serine/threonine protein phosphatase 2A 65 kDa regulatory subunit A, beta isoform antibody;serine/threonine protein phosphatase 2A, 65 kDa regulatory subunit A, beta isoform antibody;Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform antibody

SUBCELLULAR LOCATION

Secreted, Cytoplasm.

FUNCTION

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform is an enzyme that in humans is encoded by the PPP2R1B gene. This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Defects in this gene could be the cause of some lung and colon cancers. At least two transcript variants encoding different isoforms have been found for this gene.