PPP1CB Recombinant Rabbit Monoclonal Antibody [JE45-08] (ET7109-40)

UNIPROT #

P62140

PROTEIN NAME

PPP1CB

SYNONYMS

MGC3672 antibody;PP 1B antibody;PP-1B antibody;PP1B antibody;PP1B_HUMAN antibody;PP1beta antibody;PPP1CB antibody;PPP1CD antibody;Protein phosphatase 1 beta antibody;Protein phosphatase 1 catalytic subunit beta isoform antibody;Protein phosphatase 1 delta antibody;Protein phosphatase 1, catalytic subunit, beta isozyme antibody;Protein phosphatase 1, catalytic subunit, delta isoform antibody;Serine threonine protein phosphatase PP1 beta catalytic subunit antibody;Serine/threonine-protein phosphatase PP1-beta catalytic subunit antibody

SEQUENCE SIMILARITIES

Belongs to the PPP phosphatase family. PP-1 subfamily.

SUBCELLULAR LOCATION

Cytoplasm. Nucleus.

FUNCTION

In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit and a catalytic subunit. Four major families of protein phosphatase catalytic subunit have been identified, designated PP1, PP2A, PP2B (calcineurin) and PP2C. An additional protein phosphatase catalytic subunit, PPX (also known as PP4) is a putative member of a novel PP family. The PP1 family is comprised of subfamily members PP1α, PP1β and PP1γ, which are MgATP-dependent enzymes. PP1 inactivity is maintained through its association with the inhibitory protein NIPP-1 (nuclear inhibitor of PP1). Phosphorylation of NIPP-1 by cAMP-PK or casein kinase II results in the release of active PP1.