PPAR delta Rabbit Polyclonal Antibody (ER1902-24)

UNIPROT #

Q03181

PROTEIN NAME

PPAR delta

SYNONYMS

FAAR antibody;MGC3931 antibody;NR1C2 antibody;NUC1 antibody;NUCI antibody;NUCII antibody;Nuclear hormone receptor 1 antibody;Nuclear receptor subfamily 1 group C member 2 antibody;Peroxisome proliferative activated receptor delta antibody;Peroxisome proliferator-activated receptor beta (PPAR-beta) antibody;Peroxisome proliferator-activated receptor beta antibody;Peroxisome proliferator-activated receptor delta antibody;PPAR beta antibody;PPAR-beta antibody;PPAR-delta antibody;PPAR-ß antibody;PPARB antibody;ppard antibody;PPARD_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the nuclear hormone receptor family. NR1 subfamily.

TISSUE SPECIFICITY

Ubiquitous with maximal levels in placenta and skeletal muscle.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

PPARδ is a nuclear hormone receptor that governs a variety of biological processes and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer.In muscle PPAR-β/δ expression is increased by exercise, resulting in increased oxidative (fat-burning) capacity and an increase in type I fibers. Both PPAR-β/δ and AMPK agonists are regarded as exercise mimetics. In adipose tissue PPAR-β/δ increases both oxidation as well as uncoupling of oxidative phosphorylation.PPARδ may function as an integrator of transcription repression and nuclear receptor signaling. It activates transcription of a variety of target genes by binding to specific DNA elements. Well described target genes of PPARδ include PDK4, ANGPTL4, PLIN2, and CD36. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein involved in the APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, epidermal cell proliferation, and glucose and lipid metabolism.This protein has been shown to be involved in differentiation, lipid accumulation, directional sensing, polarization, and migration in keratinocytes.