PODXL Mouse Monoclonal Antibody [2-A4] (M1403-5)

UNIPROT #

O00592

PROTEIN NAME

PODXL

SYNONYMS

GCTM-2 antigen antibody;Gp2 antibody;Gp200 antibody;MGC138240 antibody;PC antibody;PCLP antibody;PCLP-1 antibody;PCLP1 antibody;Pcx antibody;Podocalyxin antibody;Podocalyxin like antibody;Podocalyxin like protein antibody;Podocalyxin-like protein 2 antibody;Podxl antibody;PODXL_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the podocalyxin family.

TISSUE SPECIFICITY

Glomerular epithelium cell (podocyte).

POST-TRANSLATIONAL MODIFICATION

N- and O-linked glycosylated. Sialoglycoprotein (By similarity).

SUBCELLULAR LOCATION

Apical cell membrane

FUNCTION

Podocalyxin, a sialoglycoprotein, is thought to be the major constituent of the glycocalyx of podocytes. It is a member of the CD34 family of transmembrane sialomucins. It is involved in the regulation of both adhesion and cell morphology and cancer progression. It functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Podocalyxin acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Sialylated, O-glycosylated glycoforms of podocalyxin expressed by colon carcinoma cells possess L-selectin and E-selectin binding activity, and may be pivotal to the metastatic spread of colon carcinoma cells.