Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
Western blot analysis of PMS2 on different lysates with Rabbit anti-PMS2 antibody (ET1605-1) at 1/500 dilution.
Lane 1: Hela cell lysate
Lane 2: Daudi cell lysate
Lane 3: MCF-7 cell lysate
Lysates/proteins at 10 µg/Lane.
Predicted band size: 96 kDa
Observed band size: 100 kDa
Exposure time: 2 minutes;
8% SDS-PAGE gel.
Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. The primary antibody (ET1605-1) at 1/500 dilution was used in 5% NFDM/TBST at room temperature for 2 hours. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1:200,000 dilution was used for 1 hour at room temperature.
DNA mismatch repair gene homologue antibody;DNA mismatch repair protein PMS2 antibody;H_DJ0042M02.9 antibody;HNPCC4 antibody;Mismatch repair endonuclease PMS2 antibody;Mismatch repair gene PMSL2 antibody;PMS 2 antibody;PMS1 protein homolog 2 antibody;PMS2 antibody;PMS2 postmeiotic segregation increased 2 antibody;PMS2 postmeiotic segregation increased 2 (S. cerevisiae) antibody;PMS2_HUMAN antibody;PMS2CL antibody;PMSL2 antibody;Postmeiotic segregation increased, S. cerevisiae, 2 antibody
Belongs to the DNA mismatch repair MutL/HexB family.
This gene is one of the PMS2 gene family members which are found in clusters on chromosome 7. Human PMS2 related genes are located at bands 7p12, 7p13, 7q11, and 7q22. Exons 1 through 5 of these homologues share high degree of identity to human PMS2 .The product of this gene is involved in DNA mismatch repair. The protein forms a heterodimer with MLH1 and this complex interacts with MSH2 bound to mismatched bases. Defects in this gene are associated with hereditary nonpolyposis colorectal cancer, with Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed.
Just like the interactions between antigens and antibodies, the higher the affinity between you and us the better.