UNIPROT #

Q15149

PROTEIN NAME

Plectin

SYNONYMS

EBS1 antibody; EBSO antibody; HD1 antibody; Hemidesmosomal protein 1 antibody; PCN antibody; pleC antibody; PLEC_HUMAN antibody; PLEC1 antibody; PLEC1b antibody; Plectin 1 antibody; Plectin 1 intermediate filament binding protein 500kDa antibody; Plectin 6 antibody; Plectin antibody; Plectin-1 antibody; PLTN antibody

SEQUENCE SIMILARITIES

Belongs to the plakin or cytolinker family.

TISSUE SPECIFICITY

Widely expressed with highest levels in muscle, heart, placenta and spinal cord.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by CDK1; regulates dissociation from intermediate filaments during mitosis.

SUBCELLULAR LOCATION

Cytoplasm, Cell junction.

FUNCTION

Plectin is an abundant cytoskeletal protein that is involved in cytoplasm stabilization. Plectin has been shown to crosslink intermediate filaments to microtubules and microfilaments, and to anchor intermediate filaments to the plasma and nuclear membranes. Plectin binds both Lamin B and vimentin, and this binding is regulated by a variety of protein kinases. Phosphorylation by PKA or PKC results in decreased binding to Lamin B, and phosphorylation by PKA enhances the plectin-vimentin interactions. Plectin is also a substrate for p34cdc2 kinase. Several alternative splice isoforms of plectin are known to exist. Mutations in human plectin are known to cause epidermolysis bullosa simplex with muscular dystrophy (EBS-MD).