PLCB2 Rabbit Polyclonal Antibody (HA500399)

UNIPROT #

Q00722

PROTEIN NAME

PLCB2

SYNONYMS

1-phosphatidylinositol-4 antibody;1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2 antibody;5-bisphosphate phosphodiesterase beta-2 antibody;FLJ38135 antibody;Phosphoinositide phospholipase C-beta-2 antibody;Phospholipase C-beta-2 antibody;PLC-beta-2 antibody;Plcb2 antibody;PLCB2_HUMAN antibody

SUBCELLULAR LOCATION

Cytosol.

FUNCTION

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2 is an enzyme that in humans is encoded by the PLCB2 gene. The gene codes for the enzyme phospholipase C β2. The enzyme catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11, as well as G-beta gamma subunits. The encoded protein is activated by G proteins and has been shown to be involved in the type 2 taste receptor signal transduction pathway. In addition, nuclear factor kappa B can regulate the transcription of this gene, whose protein product is also an important regulator of platelet responses.