Plastin L Recombinant Rabbit Monoclonal Antibody [JE48-95] (ET7109-87)

UNIPROT #

P13796

PROTEIN NAME

Plastin L

SYNONYMS

CP64 antibody;L plastin antibody;L-plastin antibody;Larval cuticle protein 1 antibody;LC64P antibody;LCP-1 antibody;LCP1 antibody;LPL antibody;Lplastin antibody;Lymphocyte cytosolic protein 1 antibody;Plastin 2 antibody;Plastin-2 antibody;PLS2 antibody;PLSL_HUMAN antibody

TISSUE SPECIFICITY

Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T-lymphocytes, neutrophils, monocytes, B-lymphocytes, and myeloid cells.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated on a serine residue in response to costimulation through TCR/CD3 and CD2 or CD28. Serine phosphorylation promotes association with the actin cytoskeleton and targeting to peripheral cell projections.

SUBCELLULAR LOCATION

Plasma membrane. Cytoskeleton.

FUNCTION

Plastin-2 is a protein that in humans is encoded by the LCP1 gene. Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.