Placental lactogen Rabbit Polyclonal Antibody (HA500128)

UNIPROT #

P0DML3

PROTEIN NAME

Placental lactogen

SYNONYMS

Choriomammotropin antibody;Chorionic somatomammotropin A antibody;chorionic somatomammotropin B antibody;chorionic somatomammotropin hormone 1 (placental lactogen) antibody;Chorionic somatomammotropin hormone 1 antibody;chorionic somatomammotropin hormone 2 antibody;Chorionic somatomammotropin hormone antibody;CS 2 antibody;CS-2 antibody;CS1 antibody;CSA antibody;CSB antibody;CSH_HUMAN antibody;CSH1 antibody;CSH2 antibody;CSMT antibody;hCS B antibody;hCS-B antibody;hCSA antibody;Lactogen antibody;mPL II antibody;PL antibody;PL1 antibody;Placental lactogen antibody;Prl3b1 antibody;prolactin family 3, subfamily b, member 1 antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome.