Placental alkaline phosphatase Recombinant Rabbit Monoclonal Antibody [JM22-53] (ET1705-21)

UNIPROT #

P05187

PROTEIN NAME

Placental alkaline phosphatase

SYNONYMS

Alkaline phosphatase antibody;Alkaline phosphatase placental antibody;Alkaline phosphatase placental type antibody;Alkaline phosphatase Regan isozyme antibody;ALP antibody;Alp1 antibody;ALPP antibody;FLJ61142 antibody;Germ-cell alkaline phosphatase antibody;nagao isozyme antibody;OTTHUMP00000164354 antibody;PALP antibody;Placental alkaline phosphatase 1 antibody;placental heat-stable alkaline phosphatase antibody;placental type antibody;PLAP antibody;PLAP-1 antibody;PLAP1 antibody;PPB1_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the alkaline phosphatase family.

TISSUE SPECIFICITY

Detected in placenta (at protein level).

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Alkaline phosphatase, placental type also known as placental alkaline phosphatase (PLAP) is an allosteric enzyme that in humans is encoded by the ALPP gene. There are at least four distinct but related alkaline phosphatases: intestinal (ALPI), placental (this enzyme), placental-like (ALPPL2), and liver/bone/kidney (ALPL) (tissue-nonspecific). The first three are located together on chromosome 2, whereas the tissue-nonspecific form is located on chromosome 1. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2, and type 3) for this form of alkaline phosphatase have been well-characterized. Alkaline phosphatase, placental type is a membrane-bound glycosylated dimeric enzyme, also referred to as the heat-stable form, that is expressed primarily in the placenta, although it is closely related to the intestinal form of the enzyme as well as to the placental-like form.