PKM2 Rabbit Polyclonal Antibody (ER1901-90)

UNIPROT #

P14618

PROTEIN NAME

PKM2

SYNONYMS

CTHBP antibody;Cytosolic thyroid hormone-binding protein antibody;KPYM_HUMAN antibody;OIP-3 antibody;Opa-interacting protein 3 antibody;p58 antibody;pkm antibody;PKM1 antibody;PKM2 antibody;Pyruvate kinase 2/3 antibody;Pyruvate kinase muscle isozyme antibody;Pyruvate kinase PKM antibody;THBP1 antibody;Thyroid hormone-binding protein 1 antibody;Tumor M2-PK antibody

SEQUENCE SIMILARITIES

Belongs to the pyruvate kinase family.

TISSUE SPECIFICITY

Specifically expressed in proliferating cells, such as embryonic stem cells, embryonic carcinoma cells, as well as cancer cells.

POST-TRANSLATIONAL MODIFICATION

ISGylated.; Under hypoxia, hydroxylated by EGLN3.; Acetylation at Lys-305 is stimulated by high glucose concentration, it decreases enzyme activity and promotes its lysosomal-dependent degradation via chaperone-mediated autophagy.; FGFR1-dependent tyrosine phosphorylation is reduced by interaction with TRIM35.

SUBCELLULAR LOCATION

Nucleus, cytoplasm.

FUNCTION

This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported.