PKC gamma Recombinant Rabbit Monoclonal Antibody [JG69-32] (ET7108-42)

UNIPROT #

P05129

PROTEIN NAME

PKC gamma

SYNONYMS

KPCG_HUMAN antibody;MGC57564 antibody;OTTHUMP00000067291 antibody;PKC-gamma antibody;PKCC antibody;PKCG antibody;PRKCG antibody;Protein kinase C gamma antibody;Protein kinase C gamma polypeptide antibody;Protein kinase C gamma type antibody;Protein kinase C, gamma antibody;SCA 14 antibody;SCA14 antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.

TISSUE SPECIFICITY

Expressed in Purkinje cells of the cerebellar cortex.

POST-TRANSLATIONAL MODIFICATION

Autophosphorylation on Thr-674 appears to regulate motor functions of junctophilins, JPH3 and JPH4.; Ubiquitinated.

SUBCELLULAR LOCATION

Cell membrane. Cytoplasm.

FUNCTION

Members of the protein kinase C (PKC) family play a key regulatory role in a variety of cellular functions, including cell growth and differentiation, gene expression, hormone secretion and membrane function. PKCs were originally identified as serine/threonine protein kinases whose activity was dependent on calcium and phospholipids. Diacylglycerols (DAG) and tumor promoting phorbol esters bind to and activate PKC. PKCs can be subdivided into at least two major classes, including conventional (c) PKC isoforms (α, βI, βII and γ) and novel (n) PKC isoforms (δ, ε, ζ, η, θ, λ/ι, µ and ν). Patterns of expression for each PKC isoform differ among tissues and PKC family members exhibit clear differences in their cofactor dependencies. For instance, the kinase activities of PKC δ and ε are independent of Ca2+. On the other hand, most of the other PKC members possess phorbol ester-binding activities and kinase activities.