Lane 1: MCF-7 cell lysate
Lane 2: Jurkat cell lysate
Lane 3: HT-29 cell lysate
Recombinant Rabbit monoclonal primary
PKC epsilon Recombinant Rabbit Monoclonal Antibody [JA38-21] (ET1704-85)
MCF-7 cell lysate, Jurkat cell lysate, HT-29 cell lysate, 293T, Hela, rat brain tissue, human kidney tissue, mouse testis tissue, human pancreas tissue, SH-SY5Y.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
KPCE_HUMAN antibody; MGC125656 antibody; MGC125657 antibody; nPKC epsilon antibody; nPKC-epsilon antibody; PKCE antibody; Pkcea antibody; PRKCE antibody; Protein kinase C epsilon antibody; Protein kinase C epsilon type antibody
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Phosphorylation on Thr-566 by PDPK1 triggers autophosphorylation on Ser-729. Phosphorylation in the hinge domain at Ser-350 by MAPK11 or MAPK14, Ser-346 by GSK3B and Ser-368 by autophosphorylation is required for interaction with YWHAB.
This is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.