PKC beta 1 Recombinant Rabbit Monoclonal Antibody [JM43-26] (ET1705-30)

UNIPROT #

P05771

PROTEIN NAME

PKC beta 1

SYNONYMS

BTN6 antibody;BTNL11 antibody;MGC26137 antibody;MOG alpha 5 antibody;MOG alpha 6 antibody;MOG AluA antibody;MOG AluB antibody;MOG antibody;MOG Ig AluB antibody;MOG_HUMAN antibody;MOGIG2 antibody;Myelin oligodendrocyte glycoprotein antibody;Myelin-oligodendrocyte glycoprotein antibody;NRCLP7 antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation on Thr-500 within the activation loop renders it competent to autophosphorylate. Subsequent autophosphorylation of Thr-642 maintains catalytic competence, and autophosphorylation on Ser-661 appears to release the kinase into the cytosol. Autophosphorylation on other sites i.e. in the N-terminal and hinge regions have no effect on enzyme activity. Phosphorylation at Tyr-662 by SYK induces binding with GRB2 and contributes to the activation of MAPK/ERK signaling cascade (By similarity).

SUBCELLULAR LOCATION

Cytoplasm. Nucleus. Membrane.

FUNCTION

Protein kinase C beta type is an enzyme that in humans is encoded by the PRKCB gene. Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. This gene could be associated with autism.