PKA R2 Recombinant Rabbit Monoclonal Antibody [JE49-49] (ET7109-92)

UNIPROT #

P13861

PROTEIN NAME

PKA R2

SYNONYMS

Alternative names;cAMP dependent protein kinase regulatory subunit alpha 2 antibody;cAMP dependent protein kinase regulatory subunit RII alpha antibody;cAMP dependent protein kinase type II alpha regulatory chain antibody;cAMP dependent protein kinase type II alpha regulatory subunit antibody;cAMP-dependent protein kinase type II-alpha regulatory subunit antibody;KAP2 antibody;KAP2_HUMAN antibody;MGC3606 antibody;PKR 2 antibody;PKR2 antibody;PRKA R2 antibody;PRKAR 2 antibody;PRKAR2 antibody;PRKAR2A antibody;Protein kinase A RII alpha subunit antibody;Protein kinase cAMP dependent regulatory type II alpha antibody

SEQUENCE SIMILARITIES

Belongs to the cAMP-dependent kinase regulatory chain family.

TISSUE SPECIFICITY

Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by the activated catalytic chain.

SUBCELLULAR LOCATION

Cell membrane, Cytoplasm, Membrane.

FUNCTION

cAMP-dependent protein kinase type II-alpha regulatory subunit is an enzyme that in humans is encoded by the PRKAR2A gene. cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent Protein Kinase, more commonly called Protein Kinase A (PKA), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of PKA is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of PKA have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins (AKAPs) and determine the subcellular localization of PKA. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER).