PI 3 Kinase p55 gamma Recombinant Rabbit Monoclonal Antibody [SR44-06] (ET1602-27)

UNIPROT #

Q92569

PROTEIN NAME

PI 3 Kinase p55 gamma

SYNONYMS

DKFZp686P05226 antibody;FLJ41892 antibody;OTTHUMP00000009783 antibody;OTTHUMP00000009786 antibody;p55 antibody;p55 gamma antibody;P55G_HUMAN antibody;p55PIK antibody;Phosphatidylinositol 3 kinase regulatory subunit gamma antibody;Phosphatidylinositol 3 kinase regulatory subunit polypeptide 3 antibody;Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55, gamma) antibody;Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma antibody;Phosphatidylinositol 3-kinase regulatory subunit gamma antibody;Phosphoinositide 3 kinase regulatory subunit 3 (gamma) antibody;Phosphoinositide 3 kinase regulatory subunit 3 antibody;Phosphoinositide 3 kinase regulatory subunit polypeptide 3 antibody;Phosphoinositide 3 kinase, regulatory subunit 3 (p55, gamma) antibody;Phosphoinositide 3 kinase, regulatory subunit, polypeptide 3 (p55, gamma) antibody;PI3 kinase p85 subunit gamma antibody;PI3-kinase regulatory subunit gamma antibody;PI3-kinase subunit p55-gamma antibody;PI3K regulatory subunit gamma antibody;Pik3r3 antibody;PtdIns 3 kinase p85 gamma antibody;PtdIns-3-kinase regulatory subunit gamma antibody;PtdIns-3-kinase regulatory subunit p55-gamma antibody

SEQUENCE SIMILARITIES

Belongs to the PI3K p85 subunit family.

TISSUE SPECIFICITY

Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle.

SUBCELLULAR LOCATION

Cytosol.

FUNCTION

Phosphatidylinositol 3-kinase is a lipid kinase that phosphorylates the inositol ring of phosphatidylinositol and related compounds at the 3’ position. PI 3-kinase p55γ (PIK3R3) is comprised of a catalytic subunit and a regulatory subunit. The human p55γ protein is composed of a rare amino terminal region followed by a proline-rich motif and two Src homology 2 (SH2) domains. PI 3-kinase p55γ mRNAs are expressed in most human fetal and adult tissues; predominant expression is observed in the adult testis. Splice variant(s) of PI 3-kinase p55γ have been identified; one of which has a deletion of 36 amino acids at the amino terminus and another which has an insertion of 59 amino acids at position 256 between the SH2 domains. Research suggests that PI 3-kinase p55γ interacts with the IGFIR (Insulin-like growth factor-I receptor) and IR (Insulin receptor) and may be involved in PI 3-kinase activation by these receptors.