Lane 1: Rat heart tissue lysate
Lane 2: Human heart tissue lysate
Rabbit polyclonal primary
Phospholamban Rabbit Polyclonal Antibody (HA500103)
Synthetic peptide within human phospholamban aa 1-31.
Rat heart tissue lysate, human heart tissue lysate, SH-SY5Y, rat heart tissue, human fetal skeletal muscle tissue, mouse heart tissue.
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Peptide affinity purified.
Predicted band size: 6 kDa.
Endoplasmic reticulum membrane, Mitochondrion membrane, Sarcoplasmic reticulum membrane, Membrane.
The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy.