Phospho-Tuberin (T1462) Recombinant Rabbit Monoclonal Antibody [JE43-81] (HA721792)

UNIPROT #

P49815

PROTEIN NAME

Phospho-Tuberin (T1462)

SYNONYMS

FLJ43106 antibody;LAM antibody;OTTHUMP00000158940 antibody;OTTHUMP00000198394 antibody;OTTHUMP00000198395 antibody;PPP1R160 antibody;Protein phosphatase 1, regulatory subunit 160 antibody;TSC complex subunit 2 antibody;tsc2 antibody;TSC2_HUMAN antibody;TSC4 antibody;TSC4 gene, formerly antibody;TSC4, formerly antibody;Tuberin antibody;Tuberous sclerosis 2 antibody;Tuberous sclerosis 2 protein antibody;Tuberous sclerosis 2 protein homolog antibody

SUBCELLULAR LOCATION

Cytoplasm, Membrane.

FUNCTION

Tuberin is a product of the TSC2 tumor suppressor gene and an important regulator of cell proliferation and tumor development. Mutations in either TSC2 or the related TSC1 (hamartin) gene cause tuberous sclerosis complex (TSC), an autosomal dominant disorder characterized by development of multiple, widespread non-malignant tumors. Tuberin is directly phosphorylated at Thr1462 by Akt/PKB. Phosphorylation at Thr1462 and Tyr1571 regulates tuberin-hamartin complexes and tuberin activity. In addition, tuberin inhibits the mammalian target of rapamycin (mTOR), which promotes inhibition of p70 S6 kinase, activation of eukaryotic initiation factor 4E binding protein 1 (4E-BP1, an inhibitor of translation initiation), and eventual inhibition of translation. Tuberin is phosphorylated on Ser939 and Thr1462 in response to PI3K activation and that the human TSC complex is a direct biochemical target of the PI3K/Akt pathway. This data complements Drosophila genetics studies suggesting the possible involvement of the tuberin-hamartin complex in the PI3K/Akt mediated insulin pathway.