Phospho-TAK1 (S439) Recombinant Rabbit Monoclonal Antibody [JE44-93] (HA722242)

UNIPROT #

O43318

PROTEIN NAME

Phospho-TAK1 (S439)

SYNONYMS

M3K7_HUMAN antibody;MAP3K 7 antibody;Map3k7 antibody;MEKK7 antibody;Mitogen activated protein kinase kinase kinase 7 antibody;Mitogen-activated protein kinase kinase kinase 7 antibody;TAK1 antibody;TGF beta activated kinase 1 antibody;TGF-beta-activated kinase 1 antibody;TGF1a antibody;Transforming growth factor beta activated kinase 1 antibody;Transforming growth factor-beta-activated kinase 1 antibody

SUBCELLULAR LOCATION

Cytoplasm, Cell membrane.

FUNCTION

Mitogen-activated protein kinase kinase kinase 7 (MAP3K7), also known as TAK1, is an enzyme that in humans is encoded by the MAP3K7 gene. This kinase has also been shown to regulate downstream cytokine expression such as TNF. Due to its regulation of TNF, TAK1 has become a novel target for the treatment of TNF mediated diseases such as auto immune disease ( Rheumatoid Arthritis, lupus, IBD) but also other cytokine mediated disorders such as chronic pain and cancer. With the advent of novel selective TAK1 inhibitors, groups have explored the therapeutic potential of TAK1 targeted therapies. One group has shown that the selective TAK1 inhibitor, Takinib developed at Duke University attenuated rheumatoid arthritis like pathology in the CIA mouse model of human inflammatory arthritis. Furthermore, pharmacological inhibition of TAK1 has shown to reduce inflammatory cytokines in particular TNF.