Recombinant Rabbit monoclonal primary
Phospho-Synapsin Ⅰ (S9) Recombinant Rabbit Monoclonal Antibody [SN63-04] (ET1611-26)
Synthetic phospho-peptide corresponding to residues surrounding ser9 of human synapsini
Rat brain tissue, mouse brain tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Phospho-Synapsin Ⅰ (S9)
Brain protein 4.1 antibody; SYN 1 antibody; SYN 1a antibody; SYN 1b antibody; SYN I antibody; SYN1 antibody; SYN1_HUMAN antibody; SYN1a antibody; SYN1b antibody; Synapsin 1 antibody; Synapsin I antibody; Synapsin-1 antibody; Synapsin1 antibody; SynapsinI antibody; SYNI antibody
Belongs to the synapsin family.
Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal.; Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles.
Cell junction, Golgi apparatus.
Synapsins are synaptic vesicle-associated phosphoproteins that regulate synaptic vesicle exocytosis and may be involved in synaptogenesis. Evidence suggests that Synapsin I, Synapsin II and Synapsin IIIa are ATP-binding proteins that are regulated by Ca2+ and calmodulin binding. Ca2+ has been shown to stimulate ATP binding to Synapsin I, to have no effect on Synapsin II and to inhibit Synapsin III. Synapsin I and Synapsin II both undergo alternative splicing to produce two forms of each protein, Synapsin la and lb and Synapsin IIa and IIb, respectively. Synapsin III gives rise to at least three isoforms: Synapsin IIIa, IIIb and IIIc. Synapsin III plays unique roles both in early axon outgrowth and in the regulation of synaptic vesicle trafficking. In cultured mouse hippocampal neurons, Synapsin III is expressed early during development, with levels peaking seven days after plating and declining thereafter. Synapsin III is highly concentrated in growth cones.