Lane 1: mouse brain tissue lysate
Lane 2: rat brain tissue lysate
Recombinant Rabbit monoclonal primary
Phospho-Smad5 (S463/465) Recombinant Rabbit Monoclonal Antibody [SY09-03] (ET1605-5)
Synthetic phospho-peptide corresponding to residues surrounding ser463 and 465 of human smad5.
Mouse brain tissue lysate, rat brain tissue lysate, SKOV-3, HepG2, human tonsil tissue, human breast carcinoma tissue, human liver tissue, mouse liver tissue, mouse brain tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
DKFZp781C1895 antibody; DKFZp781O1323 antibody; Dwfc antibody; hSmad5 antibody; JV5 1 antibody; JV5-1 antibody; MAD homolog 5 antibody; MAD, mothers against decapentaplegic homolog 5 antibody; MADH 5 antibody; MADH5 antibody; Mothers against decapentaplegic homolog 5 antibody; mothers against decapentaplegic, drosophila, homolog of, 5 antibody; Mothers against DPP homolog 5 antibody; MusMLP antibody; SMA and MAD related protein 5 antibody; SMAD 5 antibody; SMAD family member 5 antibody; SMAD, mothers against DPP homolog 5 antibody; Smad5 antibody; SMAD5_HUMAN antibody
Belongs to the dwarfin/SMAD family.
Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase.; Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1.
Smad proteins, the mammalian homologs of the Drosophila Mothers against dpp (Mad) have been implicated as downstream effectors of TGFβ/BMP signaling. Smad1 (also designated Madr1 or JV4-1), Smad5 and mammalian Smad8 (also designated Smad9 or MADH6) are effectors of BMP2 and BMP4 function while Smad2 (also designated Madr2 or JV18-1) and Smad3 are involved in TGFβ and activin-mediated growth modulation. Smad4 (also designated DPC4) has been shown to mediate all of the above activities through interaction with various Smad family members. Smad6 and Smad7 regulate the response to activin/TGFβ signaling by interfering with TGFβ-mediated phosphorylation of other Smad family members.