Phospho-RSK1 (S380) Recombinant Rabbit Monoclonal Antibody [SC05-32] (ET1610-28)

UNIPROT #

Q15418

PROTEIN NAME

Phospho-RSK1 (S380)

SYNONYMS

90 kDa ribosomal protein S6 kinase 1 antibody;dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1 antibody;dJ590P13.1 antibody;EC 2.7.11.1 antibody;HU 1 antibody;HU1 antibody;KS6A1_HUMAN antibody;MAP kinase activated protein kinase 1a antibody;MAP kinase-activated protein kinase 1a antibody;MAPK-activated protein kinase 1a antibody;MAPKAP kinase 1a antibody;MAPKAPK-1a antibody;MAPKAPK1A antibody;MGC79981 antibody;Mitogen-activated protein kinase-activated protein kinase 1A antibody;OTTHUMP00000004113 antibody;p90 RSK1 antibody;p90-RSK 1 antibody;p90rsk antibody;p90RSK1 antibody;p90S6K antibody;pp90RSK1 antibody;Ribosomal protein S6 kinase 90kD 1 antibody;Ribosomal protein S6 kinase 90kD polypeptide 1 antibody;Ribosomal protein S6 kinase 90kDa polypeptide 1 antibody;Ribosomal protein S6 kinase alpha 1 antibody;Ribosomal protein S6 kinase alpha-1 antibody;Ribosomal protein S6 kinase polypeptide 1 antibody;Ribosomal S6 kinase 1 antibody;RPS6K1 alpha antibody;rps6ka antibody;Rps6ka1 antibody;RSK 1 antibody;RSK 1 p90 antibody;RSK antibody;RSK-1 antibody;RSK1 antibody;S6K alpha 1 antibody;S6K-alpha-1 antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

POST-TRANSLATIONAL MODIFICATION

Activated by phosphorylation at Ser-221 by PDPK1. Autophosphorylated on Ser-380, as part of the activation process. May be phosphorylated at Thr-359 and Ser-363 by MAPK1/ERK2 and MAPK3/ERK1.; N-terminal myristoylation results in an activated kinase in the absence of added growth factors.

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

The family of ribosomal S6 kinases (Rsks), designated Rsk-1, Rsk-2 and Rsk-3, are important signaling intermediates that mediate responses to a broad range of ligand-activated receptor tyrosine kinases. It has been established that Rsk-3 is not activated by MAP kinase in vitro, unlike Rsk-1 and Rsk-2. A unique feature common to the three members of the Rsk family is that each possesses two non-identical complete kinase catalytic domains. The Rsk family amino-terminal kinase domain is phosphorylated on Ser 227 by 3-phosphoinositide-dependent protein kinase-1 (PDK1), which increases the kinase activity of Rsk. In the carboxy-terminal kinase domain, Rsk-1 and Rsk-2 are autophosphorylated on Ser 380 and Ser 386, respectively, which mediates the docking of PDK1 to Rsk in order to promote phosphorylation of substrates, such as histone H3.