Phospho-Rad17 (S656) Recombinant Rabbit Monoclonal Antibody [JE63-30] (HA722148)

UNIPROT #

O75943

PROTEIN NAME

Phospho-Rad17 (S656)

SYNONYMS

CCYC antibody;Cell cycle checkpoint protein antibody;Cell cycle checkpoint protein RAD17 antibody;FLJ41520 antibody;HRAD 17 antibody;hRad17 antibody;R24L antibody;Rad 17 antibody;Rad 24 antibody;RAD1 (S. pombe) homolog antibody;RAD1 homolog antibody;RAD17 antibody;RAD17 homolog (S. pombe) antibody;RAD17 homolog antibody;Rad17 like protein antibody;RAD17, S. pombe, homolog of antibody;RAD17_HUMAN antibody;RAD17Sp antibody;Rad24 antibody;Rad24, mouse, homolog of antibody;Rad24, S. cerevisiae, homolog of antibody;RF C activator 1 homolog antibody;RF C/activator 1 homolog antibody;RF-C/activator 1 homolog antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Cell cycle checkpoint protein RAD17 is a protein that in humans is encoded by the RAD17 gene. The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by ATR after the damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported. Phospho-Rad17 (S656) Antibody [JE63-30] recognizes endogenous levels of Rad17 protein only when phosphorylated at Ser656.