Lane 1: 293 cell lysate
Lane 2: Hela cell lysate
Lane 3: Jurkat cell lysate
Recombinant Rabbit monoclonal primary
Phospho-PKC alpha (T638) Recombinant Rabbit Monoclonal Antibody [JF0964] (ET1702-17)
Synthetic phospho-peptide corresponding to residues surrounding thr638 of human pkc alpha.
293 cell lysate, Hela cell lysate, Jurkat cell lysate, Hela, MCF-7, SH-SY5Y, human breast carcinoma tissue, rat brain tissue, mouse brain tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
Phospho-PKC alpha (T638)
AAG6 antibody; Aging associated gene 6 antibody; aPKC antibody; KPCA_HUMAN antibody; PKC alpha antibody; PKC-A antibody; PKC-alpha antibody; PKCA antibody; PRKACA antibody; PRKCA antibody; Protein Kinase C alpha antibody; Protein kinase C alpha type antibody
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Cytoplasm, Cell membrane, Mitochondrion membrane, Nucleus.
Members of the protein kinase C (PKC) family play a key regulatory role in a variety of cellular functions including cell growth and differentiation, gene expression, hormone secretion and membrane function. PKCs were originally identified as serine/threonine protein kinases whose activity was dependent on calcium and phospholipids. Diacylglycerols (DAG) and tumor-promoting phorbol esters bind to and activate PKC. PKCs can be subdivided into many different isoforms (α, βI, βII, γ, δ, ε, ζ, η, θ, λ/ι, μ and ν). Patterns of expression for each PKC isoform differ among tissues and PKC family members exhibit clear differences in their cofactor dependencies. For instance, the kinase activities of PKC δ and ε are independent of Ca2+. On the other hand, most of the other PKC members possess phorbol ester-binding activities and kinase activities.