Phospho-PDGFR beta (Y751) Recombinant Rabbit Monoclonal Antibody [PSH13-61] (HA723550)

UNIPROT #

P09619

PROTEIN NAME

Phospho-PDGFR beta (Y751)

SYNONYMS

Beta platelet derived growth factor receptor antibody;Beta-type platelet-derived growth factor receptor antibody;CD 140B antibody;CD140 antigen-like family member B antibody;CD140b antibody;CD140b antigen antibody;IBGC4 antibody;IMF1 antibody;JTK12 antibody;OTTHUMP00000160528 antibody;PDGF R beta antibody;PDGF-R-beta antibody;PDGFR 1 antibody;PDGFR antibody;PDGFR beta antibody;PDGFR1 antibody;PDGFRB antibody;PGFRB_HUMAN antibody;Platelet derived growth factor receptor 1 antibody;Platelet derived growth factor receptor beta antibody;Platelet derived growth factor receptor beta polypeptide antibody

SUBCELLULAR LOCATION

Cell membrane, Cytoplasmic vesicle.

FUNCTION

Platelet Derived Growth Factor (PDGF) is a mitogen for mesenchyme- and glia-derived cells. PDGF consists of two chains, A and B, which dimerize to form functionally distinct isoforms, PDGF-AA, PDGF-AB, and PDGF-BB. These three isoforms bind with different affinities to two receptor types, a and b, which are endowed with protein tyrosine kinase domains and undergo either homo- or heterodimerization as a consequence of ligand binding. Ligand stimulation of PDGFR-b leads to autophosphorylation at Tyr-857, which is the major autophosphorylation site, and Tyr-751, which is the major in vitro phosphorylation site. Autophosphorylation of Tyr-751, which lies in the kinase insert region, is required for binding of phosphatidylinositol-3 kinase to the receptor. These auto-phosphorylation events largely contribute to signal transduction through the PDGF receptor. Mutations in PDGFRB are mainly associated with the clonal eosinophilia class of malignancies.