Phospho--PAK4+PAK5+PAK6 (S474+S560+S602) Recombinant Rabbit Monoclonal Antibody [JE57-42] (HA722146)

UNIPROT #

O96013

PROTEIN NAME

Phospho--PAK4+PAK5+PAK6 (S474+S560+S602)

SYNONYMS

KIAA1142 antibody;p21 activated kinase 4 antibody;p21 Cdc42/Rac1-actiated kinase 4 antibody;P21 protein (Cdc42/Rac) activated kinase 4 antibody;p21(CDKN1A) activated kinase 4 antibody;p21-activated kinase 4 antibody;PAK 4 antibody;PAK-4 antibody;Pak4 antibody;PAK4_HUMAN antibody;Protein kinase related to S.cerevisiae STE20 effector for Cdc42Hs antibody;Serine threonine kinase PAK 4 antibody;Serine/threonine protein kinase PAK 4 antibody;Serine/threonine protein kinase PAK4 antibody;Serine/threonine-protein kinase PAK 4 antibody;EC 2.7.11.1 antibody;KIAA1264 antibody;MGC26232 antibody;p21 activated kinase 7 antibody;p21 protein (Cdc42/Rac)-activated kinase 7 antibody;p21(CDKN1A) activated kinase 7 antibody;p21-activated kinase 5 antibody;p21-activated kinase 7 antibody;PAK 5 antibody;PAK 7 antibody;PAK-5 antibody;PAK-7 antibody;PAK5 antibody;PAK7 antibody;PAK7_HUMAN antibody;Protein kinase PAK5 antibody;Serine/threonine protein kinase PAK 7 antibody;Serine/threonine-protein kinase PAK 7 antibody;CDKN1A activated kinase 6 antibody;EC 2.7.1.37 antibody;p21 activated protein kinase 6 antibody;p21 protein (Cdc42/Rac)-activated kinase 6 antibody;p21(CDKN1A) activated kinase 6 antibody;p21-activated kinase 6 antibody;p21activated kinase 6 antibody;PAK 6 antibody;PAK-6 antibody;Pak6 antibody;PAK6_HUMAN antibody;Serine threonine protein kinase PAK 6 antibody;Serine/threonine protein kinase PAK 6 antibody;Serine/threonine protein kinase PAK6 antibody;Serine/threonine-protein kinase PAK 6 antibody

SUBCELLULAR LOCATION

Cytoplasm; Mitochondrion, Cytoplasm, Nucleus; Cytoplasm, Nucleus.

FUNCTION

Serine/threonine-protein kinase PAK 4 is an enzyme that in humans is encoded by the PAK4 gene. Serine/threonine-protein kinase PAK 5 is an enzyme that in humans is encoded by the PAK5 gene. Serine/threonine-protein kinase PAK 6 is an enzyme that in humans is encoded by the PAK6 gene. PAK4 is one of six members of the PAK family of serine/threonine kinases which are divided into group I (PAK1, PAK2 and PAK3) and group II (PAK4, PAK6 and PAK5/7). PAK4 localizes in sub-cellular domains of the cytoplasm and nucleus. PAK4 regulates cytoskeleton remodeling, phenotypic signaling and gene expression, and affects directional motility, invasion, metastasis, and growth. Similar to PAK1, PAK4-signaling-dependent cellular functions also regulate both physiologic and disease processes such as cancer, as PAK4 is overexpressed and/or hyperstimulated in human cancer, at-large. The PAK5 enzyme is one of three members of Group II PAK family of serine/threonine kinases, and evolutionary conserved across species. PAK6 belongs to the Group II PAK family members. Like other family members, PAK6 is also evolutionary conserved across species. Phospho-PAK4+PAK5+PAK6 (S474+S560+S602) Antibody detects endogenous levels of PAK4, PAK5 and PAK6 only when phosphorylated at serine 474, 602, or 560, respectively.