Lane 1: Hela cell lysate
Lane 2: NIH/3T3 cell lysate
Lane 2: SH-SY5Y cell lysate
Recombinant Rabbit monoclonal primary
Phospho-PAK1(S144)+PAK2(S141)+PAK3(S139) Recombinant Rabbit Monoclonal Antibody [SU03-70] (ET1608-58)
Synthetic phospho-peptide corresponding to residues surrounding ser144 of human pak1.
Hela cell lysate, NIH/3T3 cell lysate, SH-SY5Y cell lysate, Hela, NIH/3T3, human liver carcinoma tissue, human colon carcinoma tissue, mouse brain tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Restricted to the nervous system. Highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus.
Autophosphorylated when activated by CDC42/p21.; Neddylated.
Cell membrane, ruffle membrane, nucleoplasm, Cytoplasm, focal adhesion, invadopodium, Chromosome.
This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.