Phospho-Nrf2 (S40) Recombinant Rabbit Monoclonal Antibody [SU0334] (ET1608-28)

UNIPROT #

Q16236

PROTEIN NAME

Phospho-Nrf2 (S40)

SYNONYMS

erythroid derived 2 antibody;HEBP1 antibody;like 2 antibody;NF E2 related factor 2 antibody;NF-E2-related factor 2 antibody;NF2L2_HUMAN antibody;NFE2 related factor 2 antibody;NFE2-related factor 2 antibody;Nfe2l2 antibody;Nrf 2 antibody;NRF2 antibody;Nuclear factor (erythroid derived 2) like 2 antibody;Nuclear factor antibody;nuclear factor erythroid 2 like 2 antibody;Nuclear factor erythroid 2 related factor 2 antibody;Nuclear factor erythroid 2-related factor 2 antibody;Nuclear factor erythroid derived 2 like 2 antibody

SEQUENCE SIMILARITIES

Belongs to the bZIP family. CNC subfamily.

TISSUE SPECIFICITY

Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle.

POST-TRANSLATIONAL MODIFICATION

Ubiquitinated in the cytoplasm by the BCR(KEAP1) E3 ubiquitin ligase complex leading to its degradation. In response to oxidative stress, electrophile metabolites, such as sulforaphane, modify KEAP1, leading to inhibit activity of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and activity. In response to autophagy, the BCR(KEAP1) complex is inactivated (By similarity).; Phosphorylation of Ser-40 by PKC in response to oxidative stress dissociates NFE2L2 from its cytoplasmic inhibitor KEAP1, promoting its translocation into the nucleus.; Acetylation at Lys-596 and Lys-599 increases nuclear localization whereas deacetylation by SIRT1 enhances cytoplasmic presence.; Glycation impairs transcription factor activity by preventing heterodimerization with small Maf proteins. Deglycation by FN3K restores activity.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

Nuclear factor erythroid 2-related factor 2 (NRF2), also known as nuclear factor erythroid-derived 2-like 2, is a transcription factor that in humans is encoded by the NFE2L2 gene. NRF2 is a basic leucine zipper (bZIP) protein that may regulate the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation, according to preliminary research.[6] In vitro, NRF2 binds to antioxidant response elements (AREs) in the promoter regions of genes encoding cytoprotective proteins. NRF2 induces the expression of heme oxygenase 1 in vitro leading to an increase in phase II enzymes. NRF2 also inhibits the NLRP3 inflammasome. NRF2 appears to participate in a complex regulatory network and performs a pleiotropic role in the regulation of metabolism, inflammation, autophagy, proteostasis, mitochondrial physiology, and immune responses.