Phospho-mTOR (S2481) Recombinant Rabbit Monoclonal Antibody [JE59-62] (HA721632)

UNIPROT #

P42345

PROTEIN NAME

Phospho-mTOR (S2481)

SYNONYMS

dJ576K7.1 (FK506 binding protein 12 rapamycin associated protein 1) antibody;FK506 binding protein 12 rapamycin associated protein 1 antibody;FK506 binding protein 12 rapamycin associated protein 2 antibody;FK506 binding protein 12 rapamycin complex associated protein 1 antibody;FK506-binding protein 12-rapamycin complex-associated protein 1 antibody;FKBP rapamycin associated protein antibody;FKBP12 rapamycin complex associated protein antibody;FKBP12-rapamycin complex-associated protein 1 antibody;FKBP12-rapamycin complex-associated protein antibody;FLJ44809 antibody;FRAP antibody;FRAP1 antibody;FRAP2 antibody;Mammalian target of rapamycin antibody;Mechanistic target of rapamycin antibody;mTOR antibody;MTOR_HUMAN antibody;OTTHUMP00000001983 antibody;RAFT1 antibody;Rapamycin and FKBP12 target 1 antibody;Rapamycin associated protein FRAP2 antibody;Rapamycin target protein 1 antibody;Rapamycin target protein antibody;RAPT1 antibody;Serine/threonine-protein kinase mTOR antibody

SUBCELLULAR LOCATION

Endoplasmic reticulum membrane, Golgi apparatus membrane, Mitochondrion outer membrane, Lysosome, Cytoplasm, Nucleus, Microsome membrane, Lysosome membrane, Cytoplasmic vesicle, phagosome.

FUNCTION

The mammalian target of rapamycin (mTOR), also referred to as the mechanistic target of rapamycin, and sometimes called FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a kinase that in humans is encoded by the MTOR gene. mTOR is a member of the phosphatidylinositol 3-kinase-related kinase family of protein kinases. mTOR links with other proteins and serves as a core component of two distinct protein complexes, mTOR complex 1 and mTOR complex 2, which regulate different cellular processes. In particular, as a core component of both complexes, mTOR functions as a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, autophagy, and transcription. As a core component of mTORC2, mTOR also functions as a tyrosine protein kinase that promotes the activation of insulin receptors and insulin-like growth factor 1 receptors. mTORC2 has also been implicated in the control and maintenance of the actin cytoskeleton.