Phospho-MEK3 (S189)+MEK6 (S207) Recombinant Rabbit Monoclonal Antibody [PSH11-17] (HA723299)

UNIPROT #

P46734

PROTEIN NAME

Phospho-MEK3 (S189)+MEK6 (S207)

SYNONYMS

Dual specificity mitogen activated protein kinase kinase 6 antibody;Dual specificity mitogen-activated protein kinase kinase 3 antibody;MAP kinase kinase 3 antibody;MAP kinase kinase 6 antibody;map2k3 antibody;MAP2K6 antibody;MAPK/ERK kinase 3 antibody;MAPK/ERK kinase 6 antibody;MAPKK 3 antibody;MAPKK 6 antibody;MAPKK3 antibody;MAPKK6 antibody;MEK 3 antibody;MEK 6 antibody;Mitogen activated protein kinase kinase 3 antibody;Mitogen activated protein kinase kinase 6 antibody;MKK3 antibody;MKK6 antibody;MP2K3_HUMAN antibody;PRKMK3 antibody;PRKMK6 antibody;Protein kinase, mitogen activated, kinase 6 (MAP kinase kinase 6) antibody;SAPK kinase 2 antibody;SAPKK 3 antibody;SAPKK-2 antibody;SAPKK2 antibody;SAPKK3 antibody;Stress activated protein kinase kinase 3 antibody;Stress-activated protein kinase kinase 2 antibody

SUBCELLULAR LOCATION

Cytoplasm, cytosol, membrane, nucleoplasm; Nucleus, Cytoplasm, cytoskeleton.

FUNCTION

Dual specificity mitogen-activated protein kinase kinase 3 is an enzyme that in humans is encoded by the MAP2K3 gene. The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. Dual specificity mitogen-activated protein kinase kinase 6 also known as MAP kinase kinase 6 (MAPKK 6) or MAPK/ERK kinase 6 is an enzyme that in humans is encoded by the MAP2K6 gene, on chromosome 17. MAPKK 6 is a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress-induced cell cycle arrest, transcription activation and apoptosis.