Phospho-MEK1 (T292) Recombinant Rabbit Monoclonal Antibody [SD2088] (ET1612-42)

UNIPROT #

Q02750

PROTEIN NAME

Phospho-MEK1 (T292)

SYNONYMS

Dual specificity mitogen activated protein kinase kinase 1 antibody;Dual specificity mitogen-activated protein kinase kinase 1 antibody;ERK activator kinase 1 antibody;MAP kinase kinase 1 antibody;MAP kinase/Erk kinase 1 antibody;MAP2K1 antibody;MAPK/ERK kinase 1 antibody;MAPKK 1 antibody;MAPKK1 antibody;MEK 1 antibody;Mek1 antibody;MEKK1 antibody;Mitogen activated protein kinase kinase 1 antibody;MKK 1 antibody;MKK1 antibody;MP2K1_HUMAN antibody;PRKMK1 antibody;Protein kinase mitogen activated kinase 1 (MAP kinase kinase 1) antibody;Protein kinase mitogen activated, kinase 1 antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.

TISSUE SPECIFICITY

Widely expressed, with extremely low levels in brain.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation at Ser-218 and Ser-222 by MAP kinase kinase kinases (BRAF or MEKK1) positively regulates kinase activity. Also phosphorylated at Thr-292 by MAPK1/ERK2 and at Ser-298 by PAK. MAPK1/ERK2 phosphorylation of Thr-292 occurs in response to cellular adhesion and leads to inhibition of Ser-298 phosphorylation by PAK. Autophosphorylated at Ser-218 and Ser-222, autophosphosphorylation is promoted by NEK10 following UV irradiation.; Acetylation by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus, Membrane.

FUNCTION

A family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. The prototype member of this family, designated MAP kinase kinase, or MEK-1, specifically phosphorylates the MAP kinase regulatory threonine and tyrosine residues present in the Thr-Glu-Tyr motif of ERK. A second MEK family member, MEK-2, resembles MEK-1 in its substrate specificity. MEK-3 (or MKK-3) functions to activate p38 MAP kinase, and MEK-4 (also called SEK1 or MKK-4) activates both p38 and JNK MAP kinases. MEK-5 appears to specifically phosphorylate ERK 5, whereas MEK-6 phosphorylates p38 and p38b. MEK-7 (or MKK-7) phosphorylates and activates the JNK signal transduction pathway.