Phospho-LRRK2 (S935) Recombinant Rabbit Monoclonal Antibody [JE42-11] (HA722315)

UNIPROT #

Q5S007

PROTEIN NAME

Phospho-LRRK2 (S935)

SYNONYMS

augmented in rheumatoid arthritis 17 antibody;AURA17 antibody;Dardarin antibody;Leucine rich repeat kinase 2 antibody;leucine rich repeat serine threonine protein kinase 2 antibody;Leucine-rich repeat serine/threonine-protein kinase 2 antibody;LRRK 2 antibody;LRRK2 antibody;LRRK2_HUMAN antibody;PARK 8 antibody;PARK8 antibody;RIPK7 antibody;ROCO 2 antibody;ROCO2 antibody

SUBCELLULAR LOCATION

Cytoplasmic vesicle, Perikaryon, Golgi apparatus membrane, Cell projection, axon, dendrite, Endoplasmic reticulum membrane, Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane, Endosome, Lysosome, Mitochondrion outer membrane, Cytoplasm, cytoskeleton.

FUNCTION

The LRRK2 gene encodes a protein with an armadillo repeats (ARM) region, an ankyrin repeat (ANK) region, a leucine-rich repeat (LRR) domain, a kinase domain, a RAS domain, a GTPase domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. LRRK2 interacts with the C-terminal R2 RING finger domain of parkin, and parkin interacted with the COR domain of LRRK2. Expression of mutant LRRK2 induced apoptotic cell death in neuroblastoma cells and in mouse cortical neurons. Expression of LRRK2 mutants implicated in autosomal dominant Parkinson's disease causes shortening and simplification of the dendritic tree in vivo and in cultured neurons. This is mediated in part by alterations in macroautophagy, and can be prevented by protein kinase A regulation of the autophagy protein LC3. The G2019S and R1441C mutations elicit post-synaptic calcium imbalance, leading to excess mitochondrial clearance from dendrites by mitophagy. LRRK2 is also a substrate for chaperone-mediated autophagy.