Recombinant Rabbit monoclonal primary
Phospho-HER3/ErbB3 (pY1222) Recombinant Rabbit Monoclonal Antibody [JE51-89] (ET7110-10)
Synthetic phosphopeptide corresponding to a region surrounding tyrosine 1222 of human erbb3.
Human thyroid tissue, human skin tissue, human placenta tissue.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Predicted band size: 148 kDa.
c erbB 3 antibody; c erbB3 antibody; Erb b2 receptor tyrosine kinase 3 antibody; ErbB 3 antibody; ERBB3 antibody; ERBB3 protein antibody; erbB3 S antibody; ERBB3_HUMAN antibody; Glial growth factor receptor antibody; HER 3 antibody; HER3 antibody; Human epidermal growth factor receptor 3 antibody; LCCS2 antibody; MDA BF 1 antibody; MGC88033 antibody; p180 ErbB3 antibody; p45 sErbB3 antibody; p85 sErbB3 antibody; proto-oncogene-like protein c ErbB 3 antibody; proto-oncogene-like protein c ErbB3 antibody; Proto-oncogene-like protein c-ErbB-3 antibody; Receptor tyrosine protein kinase erbB 3 antibody; Receptor tyrosine protein kinase erbB3 antibody; Receptor tyrosine-protein kinase erbB-3 antibody; Tyrosine kinase type cell surface receptor HER3 antibody; Tyrosine kinase-type cell surface receptor HER3 antibody; v erb b2 avian erythroblastic leukemia viral oncogene homolog 3 antibody; v erb b2 erythroblastic leukemia viral oncogene homolog 3 (avian) antibody; v erb b2 erythroblastic leukemia viral oncogene homolog 3 antibody
Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
Epithelial tissues and brain.
Overexpressed in a subset of human mammary tumors.
Autophosphorylated. Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase.
Cell membrane, secreted.
The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Full length ErbB-3 is overexpressed in human mammary tumors. The ErbB-3 gene also produces several alternative variants, including a secreted form which negatively regulates heregulin stimulated ErbB activation. ErbB-3 heterodimerizes with Neu and binds heregulin in order to activate phosphoinositide (PI) 3-kinase. The recruitment and activation of PI 3-kinase occurs via its interaction with phosphorylated YXXM motifs in the carboxy terminus of ErbB-3.