Phospho-HER3/ErbB3 (Y1222) Recombinant Rabbit Monoclonal Antibody [JE51-89] (ET7110-10)

UNIPROT #

P21860

PROTEIN NAME

Phospho-HER3/ErbB3 (Y1222)

SYNONYMS

c erbB 3 antibody;c erbB3 antibody;Erb b2 receptor tyrosine kinase 3 antibody;ErbB 3 antibody;ERBB3 antibody;ERBB3 protein antibody;erbB3 S antibody;ERBB3_HUMAN antibody;Glial growth factor receptor antibody;HER 3 antibody;HER3 antibody;Human epidermal growth factor receptor 3 antibody;LCCS2 antibody;MDA BF 1 antibody;MGC88033 antibody;p180 ErbB3 antibody;p45 sErbB3 antibody;p85 sErbB3 antibody;proto-oncogene-like protein c ErbB 3 antibody;proto-oncogene-like protein c ErbB3 antibody;Proto-oncogene-like protein c-ErbB-3 antibody;Receptor tyrosine protein kinase erbB 3 antibody;Receptor tyrosine protein kinase erbB3 antibody;Receptor tyrosine-protein kinase erbB-3 antibody;Tyrosine kinase type cell surface receptor HER3 antibody;Tyrosine kinase-type cell surface receptor HER3 antibody;v erb b2 avian erythroblastic leukemia viral oncogene homolog 3 antibody;v erb b2 erythroblastic leukemia viral oncogene homolog 3 (avian) antibody;v erb b2 erythroblastic leukemia viral oncogene homolog 3 antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.

TISSUE SPECIFICITY

Epithelial tissues and brain.

DEVELOPMENTAL STAGE

Overexpressed in a subset of human mammary tumors.

POST-TRANSLATIONAL MODIFICATION

Autophosphorylated. Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase.

SUBCELLULAR LOCATION

Cell membrane, secreted.

FUNCTION

The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Full length ErbB-3 is overexpressed in human mammary tumors. The ErbB-3 gene also produces several alternative variants, including a secreted form which negatively regulates heregulin stimulated ErbB activation. ErbB-3 heterodimerizes with Neu and binds heregulin in order to activate phosphoinositide (PI) 3-kinase. The recruitment and activation of PI 3-kinase occurs via its interaction with phosphorylated YXXM motifs in the carboxy terminus of ErbB-3.