Phospho-Cdk1/2/3 (T14) Recombinant Rabbit Monoclonal Antibody [JE04-37] (HA722272)

UNIPROT #

P06493

PROTEIN NAME

Phospho-Cdk1/2/3 (T14)

SYNONYMS

Cdc 2 antibody;Cdc2 antibody;CDC28A antibody;CDK 1 antibody;CDK1 antibody;CDK1_HUMAN antibody;CDKN1 antibody;CELL CYCLE CONTROLLER CDC2 antibody;Cell division control protein 2 antibody;Cell division control protein 2 homolog antibody;Cell division cycle 2 G1 to S and G2 to M antibody;Cell division protein kinase 1 antibody;Cell Divsion Cycle 2 Protein antibody;Cyclin Dependent Kinase 1 antibody;Cyclin-dependent kinase 1 antibody;DKFZp686L20222 antibody;MGC111195 antibody;p34 Cdk1 antibody;p34 protein kinase antibody;P34CDC2 antibody;Cdc2 related protein kinase antibody;cdc2-related protein kinase antibody;CDC28 antibody;CDC2A antibody;Cdk 2 antibody;CDK2 antibody;CDK2_HUMAN antibody;CDKN2 antibody;Cell devision kinase 2 antibody;Cell division protein kinase 2 antibody;Cyclin dependent kinase 2 antibody;cyclin dependent kinase 2-alpha antibody;Cyclin-dependent kinase 2 antibody;kinase Cdc2 antibody;MPF antibody;p33 protein kinase antibody;p33(CDK2) antibody;Cdk 3 antibody;Cdk3 antibody;CDK3_HUMAN antibody;CDKN3 antibody;Cell division kinase 3 antibody;Cell division protein kinase 3 antibody;Cyclin dependent kinase 3 antibody;Cyclin-dependent kinase 3 antibody;OTTHUMP00000206828 antibody;p36 antibody

SUBCELLULAR LOCATION

Nucleus, Cytoplasm, Mitochondrion.

FUNCTION

Cyclin-dependent kinases (CDKs) are a predominant group of serine/threonine protein kinases involved in the regulation of the cell cycle and its progression, ensuring the integrity and functionality of cellular machinery. These regulatory enzymes play a crucial role in the regulation of eukaryotic cell cycle and transcription, as well as DNA repair, metabolism, and epigenetic regulation, in response to several extracellular and intracellular signals. They are present in all known eukaryotes, and their regulatory function in the cell cycle has been evolutionarily conserved. The catalytic activities of CDKs are regulated by interactions with CDK inhibitors (CKIs) and regulatory subunits known as cyclins. Cyclins have no enzymatic activity themselves, but they become active once they bind to CDKs. Without cyclin, CDK is less active than in the cyclin-CDK heterodimer complex. CDKs phosphorylate proteins on serine (S) or threonine (T) residues. The specificity of CDKs for their substrates is defined by the S/T-P-X-K/R sequence, where S/T is the phosphorylation site, P is proline, X is any amino acid, and the sequence ends with lysine (K) or arginine (R). This motif ensures CDKs accurately target and modify proteins, crucial for regulating cell cycle and other functions. Deregulation of the CDK activity is linked to various pathologies, including cancer, neurodegenerative diseases, and stroke.